Category hub · Longevity & cognitive 50+
Longevity & Cellular
Peptides explored for effects on cellular aging, mitochondrial function, telomeres, and general healthspan. This is an early-stage field where excitement often outpaces the data, so we keep the framing especially cautious and clearly mark preliminary work.
Peptides in this category
9 profilesEpitalon
Epitalon (Epithalon / AEDG peptide)
Epitalon is a short, lab-made peptide (four amino acids) developed in Russia from research on the pineal gland. It is studied for possible effects on cellular aging and the telomerase enzyme. The evidence is genuinely early-stage, mostly small or older studies, so its benefits in people are far from established.
Read profileSS-31
SS-31 (Elamipretide)
SS-31, known in clinical development as elamipretide, is a mitochondria-targeting peptide studied for diseases involving mitochondrial dysfunction, including some heart and rare mitochondrial conditions. It has reached human trials, but results have been mixed and it is not approved. Longevity claims go beyond the current evidence.
Read profileAICAR
AICA riboside (acadesine), an AMPK activator
AICAR is a small molecule that activates AMPK, an enzyme cells use to sense low energy. In mice it has been studied for endurance and metabolic effects, which is why it is sometimes called an "exercise mimetic." Human evidence for fitness or longevity uses is very limited, and it is banned in sports.
Read profileFOXO4-DRI
FOXO4 D-Retro-Inverso peptide
FOXO4-DRI is an experimental "senolytic" peptide designed to selectively kill senescent (worn-out) cells. It gained attention from a single mouse study suggesting it could clear these cells and improve some aging measures. There is no human evidence, and it remains a laboratory research tool.
Read profileGlutathione
Glutathione (gamma-L-glutamyl-L-cysteinyl-glycine)
Glutathione is a tripeptide antioxidant made naturally by the body and present in every cell. It is widely sold as an oral supplement and given by IV, often marketed for "detox," immunity, or skin lightening. Evidence for many of these uses is limited or mixed, and oral absorption is debated.
Read profileHumanin
Humanin (mitochondrial-derived peptide)
Humanin is a small peptide encoded within mitochondrial DNA and studied as one of the first "mitochondrial-derived peptides." Lab and animal research links it to cell-protective and metabolic effects, and blood levels appear to fall with age. There is no approved human use, and clinical evidence is early.
Read profileMOTS-c
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c)
MOTS-c is a small mitochondrial-derived peptide studied for metabolism and exercise. In mice it has been linked to better insulin sensitivity and endurance, acting partly through the AMPK energy-sensing pathway. Human evidence is early, and it is not an approved treatment.
Read profileNAD+
Nicotinamide adenine dinucleotide
NAD+ is a coenzyme found in all living cells and essential for energy metabolism. It is marketed heavily for anti-aging, energy, and "cellular health," often via IV drips or precursor supplements like NR and NMN. The core biology is solid, but human evidence that boosting NAD+ slows aging or treats disease is limited.
Read profilePNC-27
PNC-27 (p53-derived membranolytic peptide)
PNC-27 is an experimental peptide based on part of the p53 protein, studied in the lab for selectively destroying cancer cells. The interest comes from cell-culture experiments, not from human use. There are no clinical trials, and marketing claims about cancer benefit are not supported by human evidence.
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